Eisen may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Iron Dextran is reported as an ingredient of Eisen in the following countries:
International Drug Name Search
Additiva Flatusan may be available in the countries listed below.
Simeticone is reported as an ingredient of Additiva Flatusan in the following countries:
International Drug Name Search
Retterspitz Darmreinigungspulver may be available in the countries listed below.
Magnesium Sulfate heptahydrate (a derivative of Magnesium Sulfate) is reported as an ingredient of Retterspitz Darmreinigungspulver in the following countries:
International Drug Name Search
Class: Azoles
ATC Class: D01AC09
VA Class: DE102
Chemical Name: (±)-1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate
Molecular Formula: C18H15Cl3N2S•HNO3
CAS Number: 61318-91-0
Brands: Exelderm
Antifungal; azole (imidazole derivative).1 2 3 18
Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Microsporum canis, Trichophyton mentagrophytes, or T. rubrum.1 2 3 5 11 12 13 14 15 20 21 25 26 27 39 40 43 45 56
Treatment of tinea pedis (athlete’s foot) 3 5 11 12 13 14 20 21 25 27 39 40 43 45 caused by E. floccosum, M. canis, T. mentagrophytes, or T. rubrum.2 3 5 11 12 13 14 15 20 21 25 26 27 39 40 43 45 56
Topical antifungals usually effective for treatment of uncomplicated tinea corporis or tinea cruris.40 58 An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.39 40 43 44 45 56
Topical antifungals usually effective for treatment of uncomplicated tinea pedis.45 56 59 An oral antifungal may be necessary for treatment of hyperkeratotic areas on the soles, for chronic moccasin-type (dry-type) tinea pedis,15 and for tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).40 45 56
Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).1 2 3 8 10
Topical antifungals usually effective;39 41 42 44 53 60 an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or failed to respond to or have frequent relapses with topical therapy.41 42 44 53 58
Treatment of cutaneous candidiasis† caused by Candida albicans.9 22
Apply topically to the skin as a 1% cream or solution.1 3
Do not apply to the eye or administer orally or intravaginally.1 3 19
Apply a sufficient amount of cream or solution; rub gently into affected area and immediately surrounding healthy skin.1 3 14 15 26
Apply 1% cream or solution once or twice daily1 3 14 15 26 for 3 weeks.1 3
If clinical improvement does not occur after 4–6 weeks of treatment, reevaluate diagnosis.3 58
Apply 1% cream twice daily3 14 15 26 for 4 weeks.1 3 58
If clinical improvement does not occur after 4–6 weeks of treatment, reevaluate diagnosis.3 58 Chronic moccasin-type (dry-type) tinea pedis may require 4–8 weeks or longer.15 40
Apply 1% cream or solution once or twice daily1 3 14 15 26 for 3 weeks.1 3
If clinical improvement does not occur after 4–6 weeks of treatment, reevaluate diagnosis.1 3
No special population dosage recommendations at this time.1 3
Known hypersensitivity to sulconazole or any ingredient in the formulation.1 3 19 58
For external use only.1 3 Use only for topical application to the skin; not for ophthalmic or intravaginal use.1 3 19
Embryotoxicity demonstrated in animals receiving oral sulconazole.1 3 19
Contact dermatitis reported following topical application of sulconazole2 11 or other imidazole-derivative azole antifungals.5 28 29 30 46 47 48
If irritation or sensitivity occurs, discontinue the drug and initiate appropriate therapy.1 3
Possible cross-sensitization among the imidazoles.4 28 29 30 46 47 48
Prior to initiation of treatment, confirm diagnosis by direct microscopic examination of scrapings from infected tissue mounted in potassium hydroxide (KOH) or by culture.39 40 45 56 58
Category C.1 3 (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
Not known whether distributed into milk.1 3 Caution advised.1 3
Safety and efficacy not established.1 3
Insufficient data from clinical studies to determine whether patients ≥65 years of age respond differently than younger adults.1 3 Clinical experience to date has not identified differences in responses between geriatric patients and younger adults.1 3
Pruritus,2 3 5 8 9 10 15 22 burning,1 3 5 8 10 15 22 25 stinging,1 3 10 15 erythema.2 3 5 8 10 22
Weak inducer of CYP1A1 and CYP2B1.35
Potential pharmacokinetic interaction with drugs metabolized by CYP1A1 or 2B1;38 interaction unlikely with topical administration of sulconazole58 since only low amounts absorbed following topical application to skin.2 16 19 34
Low amounts of sulconazole are absorbed systemically following topical application to skin.2 16 19 34
Not known whether sulconazole is distributed into milk.1 3
Systemically absorbed drug is excreted in urine (6.7%) and feces (2%).16
≤40°C.3
≤40°C; protect from light.1 3
Imidazole-derivative azole antifungal.1 2 3 18
Usually fungistatic; may be fungicidal at high concentrations against very susceptible organisms.2 7
Presumably exerts its antifungal activity by altering cellular membranes, resulting in increased membrane permeability, secondary metabolic effects, and growth inhibition.2 24 Fungistatic activity may result from interference with ergosterol synthesis.2 43 57
Spectrum of antifungal activity includes many fungi, including yeasts and dermatophytes.1 2 3 7 17 18 23 37 Also has in vitro activity against some gram-positive bacteria.1 2 3 18 37
Dermatophytes: Active in vitro against Epidermophyton floccosum,1 2 3 18 Microsporum audouinii,18 M. canis,1 2 3 M. gypseum,2 18 Trichophyton mentagrophytes,1 2 3 18 T. rubrum,1 2 3 18 T. tonsurans,2 18 and T. violaceum.2
Candida: Active in vitro against Candida albicans,2 7 17 18 23 C. glabrata (formerly Torulopsis glabrata),2 C. guilliermondii,2 17 C. krusei,2 17 C. parapsilosis,2 17 C. pseudotropicalis,2 17 and C. tropicalis.2 17
Other fungi: Active in vitro against Malassezia furfur (Pityrosporum orbiculare or P. ovale).1 2 3 Also active in vitro against Aspergillus,2 Blastomyces dermatitidis,2 Cryptococcus neoformans,2 18 Histoplasma capsulatum,2 and Paracoccidioides brasiliensis.2 17 23
Bacteria: Active in vitro against Bacillus subtilis,2 Clostridium perfringens,2 C. tetani,2 C. botulinum,2 Enterococcus faecalis,2 Erysipelothrix rhusiopathiae,6 Micrococcus luteus,2 Propionibacterium acnes,18 Staphylococcus aureus,2 S. epidermidis,2 and S. saprophyticus.2
Cross-resistance can occur among the azole antifungals.23 Some C. albicans isolates from patients undergoing long-term azole antifungal therapy show decreased in vitro susceptibility to sulconazole and other imidazole-derivative antifungals as well as to triazole derivatives.23
Importance of completing full course of treatment, even if symptoms improve.1 3
Importance of contacting clinician if skin condition worsens during treatment or if improvement does not occur after completing full course of therapy.1 3
Importance of discontinuing use and consulting clinician if treated area becomes irritated.1 3
Importance of applying to affected areas as directed1 3 and avoiding contact with eyes and not applying intravaginally.1 3 19
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.1 3
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1 3
Importance of informing patients of other important precautionary information.1 3 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Topical | Cream | 1% | Exelderm (with propylene glycol) | Westwood-Squibb |
Solution | 1% | Exelderm (with propylene glycol) | Westwood-Squibb |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Exelderm 1% Cream (RANBAXY LABORATORIES): 30/$95.05 or 90/$268.3
Exelderm 1% Solution (RANBAXY LABORATORIES): 30/$79.99 or 90/$225.97
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions July 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
1. Westwood Squibb Pharmaceuticals. Exelderm (sulconazole nitrate) 1% solution prescribing information. Princeton, NJ; 2006 Apr.
2. Benfield P, Clissold SP. Sulconazole: a review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs. 1988; 35:143-53. [IDIS 239722] [PubMed 3281821]
3. Westwood Squibb Pharmaceuticals. Exelderm (sulconazole nitrate) 1% cream prescribing information. Buffalo, NY; 2003 May 29.
4. Bigardi AS, Pigatto PD, Altomare G. Allergic contact dermatitis due to sulconazole. Contact Dermatitis. 1992; 26:281-2. [PubMed 1395584]
5. Tanenbaum L, Anderson C, Rosenberg MJ et al. Sulconazole nitrate 1.0 percent cream: a comparison with miconazole in the treatment of tinea pedis and tinea cruris/corporis. Cutis. 1982; 30:105-7, 115, 118. [PubMed 6749440]
6. Nolting S, Strauss WB. Treatment of impetigo and ecthyma: a comparison of sulconazole with miconazole. Int J Dermatol. 1988; 27:716-9. [PubMed 3069760]
7. Beggs WH. Influence of growth phase on the susceptibility of Candida albicans to butoconazole, oxiconazole, and sulconazole. J Antimicrob Chemother. 1985; 16:397-9. [PubMed 3902762]
8. Tham SN. Treatment of pityriasis versicolor: comparison of sulconazole nitrate 1% solution and clotrimazole 1% solution. Australas J Dermatol. 1987; 28:123-5. [PubMed 3332758]
9. Rajan VS, Thirumoorthy T. Treatment of cutaneous candidiasis: a double blind, parallel comparison of sulconazole nitrate 1% cream and clotrimazole 1% cream. Australas J Dermatol. 1983;24:33-6.
10. Tanenbaum L, Anderson C, Rosenberg MJ et al. 1% sulconazole cream v 2% miconazole cream in the treatment of tinea versicolor. Arch Dermatol. 1984; 120:216-9. [IDIS 181082] [PubMed 6364994]
11. Lassus A, Forström S, Salo O. A double-blind comparison of sulconazole nitrate 1% cream with clotrimazole 1% cream in the treatment of dermatophytoses. Br J Dermatol. 1983; 108:195-8. [IDIS 166239] [PubMed 6337618]
12. Avila JM. Treatment of dermatomycoses with sulconazole 1% nitrate cream or miconazole nitrate 2% cream: a double-blind comparative study. Curr Ther Res. 1985; 38:328-33.
13. Woscoff A, Carabeli S. Treatment of tinea pedis with sulconazole nitrate 1% cream or miconazole nitrate 2% cream. Curr Ther Res. 1986; 39:753-7.
14. Cuce LC. Sulconazole nitrate 1% cream vs clotrimazole 1% cream in the treatment of tinea pedis. Curr Ther Res. 1989; 45:421-7.
15. Akers WA, Lane A, Lynfield Y et al. Sulconazole nitrate 1% cream in the treatment of chronic moccasin-type tinea pedis caused by Trichophyton rubrum. J Am Acad Dermatol. 1989; 21:686-9. [PubMed 2681281]
16. Franz TJ, Lehman P. Percutaneous absorption of sulconazole nitrate in humans. J Pharm Sci. 1988; 77:489-91. [IDIS 242452] [PubMed 3171926]
17. Hernández Molina JM, Llosá J, Martinez Brocal A et al. In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp. Mycopathologia. 1992; 118:15-21. [PubMed 1406898]
18. Westwood Squibb Pharmaceuticals. Exelderm (sulconazole nitrate 1%) cream and solution product monograph. Buffalo, NY.
19. Westwood Squibb Pharmaceuticals. Exelderm (sulconazole nitrate) product information. Buffalo, NY; 1990 Aug.
20. McVie DH, Littlewood S, Allen BR et al. Sulconazole versus clotrimazole in the treatment of dermatophytosis. Clin Exp Dermatol. 1986; 11:613-8. [PubMed 3311492]
21. Lassus A, Forsström S. A double-blind parallel study comparing sulconazole with econazole in the treatment of dermatophytoses. Mykosen. 1984; 27:592-8. [PubMed 6395015]
22. Tanenbaum L, Anderson C, Rosenberg M et al. A new treatment for cutaneous candidiasis: sulconazole nitrate cream 1%. Intl J Dermatol. 1983; 22:318-20.
23. Odds FC, Webster CE, Abbott AB. Antifungal relative inhibition factors: BAY 1-9139, bifonazole, butoconazole, isoconazole, itraconazole (R 51211), oxiconazole, Ro 14-4767/002, sulconazole, terconazole and vibunazole (BAY n-7133) compared in vitro with nine established antifungal agents. J Antimicrob Chemother. 1984; 14:105-14. [PubMed 6094418]
24. Sud IJ, Chou DL, Feingold DS. Effect of free fatty acids on liposome susceptibility to imidazole antifungals. Antimicrob Agents Chemother. 1979; 16:660-3. [PubMed 393166]
25. Gip L, Forsström S. A double-blind parallel study of sulconazole nitrate 1% cream compared with miconazole nitrate 2% cream in dermatophytoses. Mykosen. 1983; 26:231-41. [PubMed 6877272]
26. Tanenbaum L, Taplin D, Lavelle C et al. Sulconazole nitrate cream 1 percent for treating tinea cruris and corporis. Cutis. 1989; 44:344-7. [PubMed 2805811]
27. Qadripur SA. Double-blind parallel comparison of sulconazole nitrate, 1% cream and powder, with econazole, 1% cream and powder, in the treatment of cutaneous dermatophytoses. Curr Ther Res. 1984; 35:753-8.
28. Machet L, Vaillant L, Muller C et al. Contact dermatitis and cross-sensitivity from sulconazole nitrate. Contact Dermatitis. 1992; 26:352-3. [PubMed 1395603]
29. Raulin C, Frosch PJ. Contact allergy to imidazole antimycotics. Contact Dermatitis. 1988; 18:76-80. [PubMed 2966706]
30. Raulin C, Frosch PJ. Contact allergy to oxiconazole. Contact Dermatitis. 1987; 16:39-40. [PubMed 3816206]
31. Thomas AH. Suggested mechanisms for the antimycotic activity of the polyene antibiotics and the N-substituted imidazoles. J Antimicrob Chemother. 1986; 17:269-79. [PubMed 3516967]
32. Sud IJ, Feingold DS. Mechanisms of action of the antimycotic imidazoles. J Invest Dermatol. 1981; 76:438-41. [IDIS 133194] [PubMed 7017013]
33. Bristol-Myers Squibb. Vagistat-1 (tioconazole) 6.5% vaginal ointment prescribing information. In: Physicians’ desk reference. 51st ed. Montvale, NJ: Medical Economics Company Inc; 1997:783.
34. Fujihara M, Hirakoso K, Harigaya S. Pharmacokinetics of sulconazole nitrate (1) fate in rats after application to the skin. Oyo Yakuri Pharmacomet. 1984; 28:145-54.
35. Raffali F, Rougier A, Roguet R. Measurement and modulation of cytochrome-P450- dependent enzyme activity in cultured human keratinocytes. Skin Pharmacol. 1994; 7: 345-54. [PubMed 7946378]
36. Richardson K, Cooper K, Marriott MS et al. Discovery of fluconazole, a novel antifungal agent. Clin Infect Dis. 1990; 12(Suppl 3):S267-1.
37. Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988; 1:187-217. [PubMed 3069196]
38. Cropp JS, Bussey HI. A review of enzyme induction of warfarin metabolism with recommendations for patient management. Pharmacotherapy. 1997; 17: 917-28.
39. Gupta AK, Einarson TR, Summerbell RC et al. An overview of topical antifungal therapy in dermatomycoses: a North American perspective. Drugs. 1998; 55:645-74. [PubMed 9585862]
40. Piérard GE, Arrese JE, Piérard-Franchimont C. Treatment and prophylaxis of tinea infections. Drugs. 1996; 52:209-24. [PubMed 8841739]
41. Sunenshine PJ, Schwartz RA, Janniger CK. Tinea versicolor: an update. Cutis. 1998; 61:65-72. [PubMed 9515210]
42. Assaf RR, Weil ML. The superficial mycoses. Dermatol Clin. 1996; 14:57- 67. [PubMed 8821158]
43. Lesher JL. Recent developments in antifungal therapy. Dermatol Clin. 1996; 14:163-9. [PubMed 8821170]
44. Hay RJ. Dermatophytosis and other superficial mycoses. In: Mandel GL, Douglas RG Jr, Bennett JE, eds. Principles and practices of infectious disease. 4th ed. New York: Churchill Livingston; 1995: 2375-86.
45. Drake LA, Dincehart SM, Farmer ER et al. Guidelines of care for superficial mycotic infections of the skin: tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. J Am Acad Dermatol. 1996; 34:282-6. [IDIS 363962] [PubMed 8642094]
46. Jones SK, Kennedy CTC. Contact dermatitis from tioconazole. Contact Dermatitis. 1990; 22:122-3. [PubMed 2138969]
47. Baes H. Contact sensitivity to miconazole with ortho-chloro cross-sensitivity to other imidazoles. Contact Dermatitis. 1991; 24:89-93. [PubMed 1828223]
48. Marren P, Powell S. Contact sensitivity to tioconazole and other imidazoles. Contact Dermatitis. 1992; 27:129-30. [PubMed 1395626]
49. Ortho. Monistat 3 (miconazole nitrate) 200 mg vaginal suppositories prescribing information. In: Physicians’ desk reference. 51st ed. Montvale, NJ: Medical Economics Company Inc; 1997:1903-4.
50. Ortho. Spectazole (econazole nitrate) 1% cream prescribing information (dated 1996 Jun). In: Physicians’ desk reference. 52nd ed. Montvale, NJ: Medical Economics Company Inc; 1998:1989.
51. Janssen Pharmaceutica. Nizoral (ketoconazole) tablets prescribing information (dated 1996 Jun). In: Physicians’ desk reference. 52nd ed. Montvale, NJ: Medical Economics Company Inc; 1998:1306-8.
52. Alexander BD, Perfect JR. Antifungal resistance trends towards the year 2000: implications for therapy and new approaches. Drugs. 1997; 54:657-78. [PubMed 9360056]
53. Drake LA, Dincehart SM, Farmer ER et al. Guidelines of care for superficial mycotic infections of the skin: pityriasis (tinea) versicolor. J Am Acad Dermatol. 1996; 34:287-9. [IDIS 363963] [PubMed 8642095]
54. Drake LA, Dincehart SM, Farmer ER et al. Guidelines of care for superficial mycotic infections of the skin: tinea capitis and tinea barbae. J Am Acad Dermatol. 1996; 34:290-4. [IDIS 363964] [PubMed 8642096]
55. Elewski B. Tinea capitis. Dermatol Clin. 1996; 14:23-31. [PubMed 8821154]
56. Crissey JT. Common dermatophyte infections: a simple diagnostic test and current management. Postgrad Med. 1998; 103:191-205. [IDIS 401902] [PubMed 9479316]
57. Anon. Antifungal agents and their use in Candida infections. In: Odds FC, ed. Candida and candidosis. 2nd ed. Philadelphia: Bailliere Tindall; 1988:293-313.
58. Reviewers’ comments (personal observations).
59. Naftifine Gel Study Group. Naftifine gel in the treatment of tinea pedis: two double- blind multicenter studies. Cutis. 1991; 48:85-8. [PubMed 1868748]
60. Aste N, Pau M, Pinna AL et al. Clinical efficacy and tolerability of terbinafine in patients with pityriasis versicolor. Mycoses. 1991; 34:353-7. [PubMed 1803242]
Generic Name: phenylephrine (FEN il EFF rin)
Brand Names: Ah-Chew D, Dimetapp Cold Drops, Lusonal, Nasop, Nasop12, PediaCare Children's Decongestant, Phenyl-T, Sudafed PE, Sudafed PE Children's Nasal Decongestant, Sudafed PE Quick Dissolve, Sudogest PE, Triaminic Thin Strips Cold
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Phenylephrine is used to treat nasal congestion and sinus pressure caused by allergies, the common cold, or the flu. Phenylephrine may be used to treat congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes.
Phenylephrine may also be used for other purposes not listed in this medication guide.
You should not use this medication if you are allergic to phenylephrine.
Do not use phenylephrine if you have used linezolid (Zyvox) or procarbazine (Matulane), or if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life-threatening side effects can occur if you take phenylephrine before these other drugs have cleared from your body.
Before you take phenylephrine, tell your doctor if you are allergic to any decongestants, or if you have heart disease, heart rhythm disorder, high blood pressure, circulation problems, diabetes, glaucoma, a thyroid disorder, kidney disease, an enlarged prostate or urination problems, anxiety, sleep problems, bipolar disorder or other mental illness.
Phenylephrine may interact with heart or blood pressure medications, antidepressants, diabetes medications, migraine headache medications, and other decongestants.
Never take more of the medicine than directed on the label or prescribed by your doctor.
You should not use this medication if you are allergic to phenylephrine.
Do not use phenylephrine if you have used linezolid (Zyvox) or procarbazine (Matulane), or if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life-threatening side effects can occur if you take phenylephrine before these other drugs have cleared from your body.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take phenylephrine, tell your doctor if you are allergic to any decongestants, or if you have:
heart disease, heart rhythm disorder;
high blood pressure;
circulation problems (such as Raynaud's syndrome);
diabetes;
glaucoma;
a thyroid disorder;
an enlarged prostate or urination problems;
sleep problems, anxiety; or
mental illness such as bipolar disorder.
Disintegrating and liquid forms of cold medicine may contain sugar or artificial sweeteners (phenylalanine). This would be important to know if you have diabetes or phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about sugar or phenylalanine.
Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.
Measure the liquid form of phenylephrine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
The chewable phenylephrine tablet must be chewed thoroughly before you swallow it.
To use the phenylephrine disintegrating strip, place one strip on your tongue and allow it to dissolve without chewing.
To use the disintegrating tablet, make sure your hands are dry and peel back the foil from the blister package. Place the tablet on your tongue. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Phenylephrine is usually taken every 4 hours. Follow the directions on the medicine label. Never take more of the medicine than directed on the label or prescribed by your doctor.
If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.
Throw away any unused phenylephrine after the expiration date on the label has passed. Do not flush this medication down a toilet. Ask your pharmacist about the safest way to dispose of unused medicines.
Cold medicine is usually taken only as needed, so you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include feeling restless or nervous, severe dizziness, sweating, vomiting, hallucinations, fast or uneven heart rate, fainting, seizure (convulsions), and weak or shallow breathing.
Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
severe dizziness, restless feeling, nervousness, or insomnia;
unusual thoughts or behavior;
feeling like you might pass out;
fast, pounding, or uneven heartbeat;
tremors or shaking;
numbness, tingling, or cold feeling in your hands or feet; or
urinating less than usual or not at all.
Less serious side effects may include:
headache, dizziness;
feeling excited or restless (especially in children);
upset stomach; or
mild sleep problems.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medications you use, especially:
other decongestants, including nasal sprays;
digoxin (digitalis, Lanoxin);
medicine to treat diabetes;
medicines to treat high blood pressure such as reserpine, methyldopa (Aldomet), and others;
migraine headache medicine such as ergotamine (Ergomar), naratriptan (Amerge), sumatriptan (Imitrex) or zolmitriptan (Zomig);
an antidepressant such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal), sotalol (Betapace), and others; or
a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others.
This list is not complete and there may be other drugs that can interact with phenylephrine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
See also: Sudafed PE side effects (in more detail)
Generic Name: chlorpheniramine and pseudoephedrine (klor fen EER a meen and soo doe e FED rin)
Brand Names: AccuHist Drops, Allerest Maximum Strength, Brexin L.A., Colfed-A, D-Amine-SR, Dayquil Allergy, Deconamine, Dicel, Dicel Chewables, Dura-Tap/PD, Durafed, Duratuss DA, Dynahist-ER Pediatric, Genaphed Plus, Histade, Histex, Kronofed-A, Kronofed-A-Jr, LoHist-D, Mintex, Neutrahist Drops, Re2+30, Rescon-Ed, Suclor, SudaHist, Sudal-12 Chewable, Sudal-12 Tannate, Sudogest Cold & Allergy, SudoGest Sinus & Allergy, Tavist-DA, Triaminic Cold and Allergy, Triaminic Softchew Cold and Allergy, Triaminic Softchews Allergy Runny Nose and Congestion
Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
The combination of chlorpheniramine and pseudoephedrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.
Chlorpheniramine and pseudoephedrine may also be used for other purposes not listed in this medication guide.
There are many brands and forms of this medication available and not all brands are listed on this leaflet.
Do not use this medication during an asthma attack.
Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
severe or uncontrolled high blood pressure;
severe coronary artery disease;
narrow angle glaucoma;
a stomach ulcer;
if you are unable to urinate; or
if you are having an asthma attack.
Ask a doctor or pharmacist if it is safe for you to take this medication if you have:
diabetes;
glaucoma;
circulation problems;
heart disease or high blood pressure;
overactive thyroid;
a seizure disorder such as epilepsy;
asthma, emphysema or chronic bronchitis; or
urination problems or an enlarged prostate.
Artificially sweetened liquid cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.
The chewable tablet must be chewed before swallowing.
Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.
If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.
Since cold medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
fast or pounding heartbeats;
confusion, hallucinations, unusual thoughts or behavior;
severe dizziness, anxiety, restless feeling, nervousness;
urinating less than usual or not at all;
easy bruising or bleeding, unusual weakness; or
seizure (black-out or convulsions).
Less serious side effects may include:
blurred vision;
dry nose or mouth;
nausea, stomach pain, constipation, loss of appetite;
dizziness, drowsiness;
problems with memory or concentration;
ringing in your ears; or
feeling restless or excited (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.
Tell your doctor about all other medications you use, especially:
mecamylamine (Inversine);
methyldopa (Aldomet);
reserpine;
a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or
an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), nortriptyline (Pamelor), and others.
This list is not complete and other drugs may interact with chlorpheniramine and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Finadyne may be available in the countries listed below.
In some countries, this medicine may only be approved for veterinary use.
Flunixin meglumine (a derivative of Flunixin) is reported as an ingredient of Finadyne in the following countries:
International Drug Name Search
